I thought one permutation of the scientific, sci fi nature of magitech by synergysing it with BLAME! was making a truly VAST world that was a completely artificial construct where it and the remnants of humanity was threatened with destruction by dysfunctional beings created long ago. BLAME! is a lot like Necromunda.
One further way of going is that the world is surrounded by a computer generated dimension, the Wired, where anyone's dreams can come true. In this realm the basic geographical area is called a site. Perhaps as a dreamworld it lives only in people's heads but they think they are outside reality which may in fact be true.
